Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gastroesophageal Reflux Disease II: Clinical Features and Management01:29

Gastroesophageal Reflux Disease II: Clinical Features and Management

1.1K
Gastroesophageal reflux disease, or GERD, is a persistent medical condition that affects many individuals worldwide. Its clinical manifestations can vary greatly, making diagnosis and management challenging for healthcare professionals. The following is a comprehensive overview of the clinical manifestations, assessment, and management strategies for GERD.
Clinical Manifestations
GERD presents itself in a multitude of ways, with symptoms varying from person to person. The hallmark symptoms are...
1.1K
Gastroesophageal Reflux Disease01:25

Gastroesophageal Reflux Disease

39
Gastroesophageal reflux disease (GERD) is the backward flow of stomach contents (acid, pepsin, or bile) into the esophagus, causing mucosal inflammation known as esophagitis. It results from failure of antireflux mechanisms, mainly the lower esophageal sphincter (LES), influenced by mechanical and physiological factors.Etiology and Risk FactorsGERD develops when LES function is weakened or when intra-abdominal pressure increases. Risk factors include aging, obesity, and sliding hiatal hernia,...
39
Gastroesophageal Reflux Disease I: Meaning and Pathophysiology01:29

Gastroesophageal Reflux Disease I: Meaning and Pathophysiology

2.0K
Gastroesophageal Reflux Disease (GERD) involves the recurrent backflow of the stomach or duodenal contents into the esophagus, leading to troublesome symptoms and potential esophageal mucosal damage. Although GERD is often referred to as a disease, it is more accurately described as a syndrome, as it encompasses a range of symptoms and complications rather than a singular pathological entity, impacting a large number of individuals as the most prevalent upper gastrointestinal problem. Roughly...
2.0K
Hiatal Hernia01:25

Hiatal Hernia

67
A hiatal hernia is the abnormal protrusion of the stomach or other abdominal organs through the esophageal hiatus of the diaphragm into the thoracic cavity.Normally, the gastroesophageal junction (GEJ) lies below the diaphragm and is supported by the phrenoesophageal membrane, the diaphragmatic crura, and connective tissues. Weakening of these structures—due to aging, congenital defects like a short esophagus, or increased intra-abdominal pressure from coughing, obesity, pregnancy, or...
67
Other Disorders of Digestive System01:30

Other Disorders of Digestive System

1.7K
The gastrointestinal tract is susceptible to various disorders. If the lower esophageal sphincter is damaged, stomach acid can flow back into the esophagus, causing irritation and inflammation of the lining. This condition is called gastroesophageal reflux disease (known as heartburn) and may cause chest pain and difficulty swallowing. In the stomach, prolonged use of nonsteroidal anti-inflammatory drugs like aspirin, chronic alcohol consumption, bacterial infections such as Helicobacter...
1.7K
Barrett Esophagus-II: Clinical Manifestations and Management01:21

Barrett Esophagus-II: Clinical Manifestations and Management

1.8K
Individuals with Barrett's esophagus are often asymptomatic, but they may experience symptoms commonly associated with GERD, such as heartburn and acid regurgitation. Additional symptoms can include difficulty swallowing, chest pain, unintentional weight loss, blood in the stool (which may appear black, tarry, or bloody), and episodes of vomiting.
To diagnose Barrett's esophagus, healthcare providers often recommend an endoscopy for those showing symptoms of acid reflux. The procedure...
1.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

S1 Guideline of the German Society for Neurogastroenterology and Motility (DGNM) on Functional Dyspepsia (FD), a Disorder of Gut-Brain Interaction (DGBI) [English Language Edition].

Gastroenterology research and practice·2026
Same author

Zeitschrift fur Gastroenterologie·2022
Same author

Zeitschrift fur Gastroenterologie·2021
Same author

MMW Fortschritte der Medizin·2020
Same author

MMW Fortschritte der Medizin·2020
Same author

MMW Fortschritte der Medizin·2019
Same journal

MMW Fortschritte der Medizin·2026
Same journal

MMW Fortschritte der Medizin·2026
Same journal

MMW Fortschritte der Medizin·2026
Same journal

MMW Fortschritte der Medizin·2026
Same journal

MMW Fortschritte der Medizin·2026
Same journal

MMW Fortschritte der Medizin·2026
See all related articles

Related Experiment Video

Updated: Apr 28, 2026

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
06:46

Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

Published on: December 14, 2020

2.8K

[Functional heartburn--update 2013].

M Storr

    MMW Fortschritte Der Medizin
    |June 18, 2014
    PubMed
    Summary
    This summary is machine-generated.

    Functional heartburn, a common condition unresponsive to proton pump inhibitors (PPIs), requires careful diagnosis. Treatment involves patient education, symptom identification, and realistic goal setting for effective management.

    More Related Videos

    The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
    06:40

    The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management

    Published on: June 29, 2019

    6.3K
    Cooling or Warming the Esophagus to Reduce Esophageal Injury During Left Atrial Ablation in the Treatment of Atrial Fibrillation
    06:25

    Cooling or Warming the Esophagus to Reduce Esophageal Injury During Left Atrial Ablation in the Treatment of Atrial Fibrillation

    Published on: March 15, 2020

    12.9K

    Related Experiment Videos

    Last Updated: Apr 28, 2026

    Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring
    06:46

    Simultaneous Laryngopharyngeal and Conventional Esophageal pH Monitoring

    Published on: December 14, 2020

    2.8K
    The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management
    06:40

    The Dyspepsia Educational Tool As a Novel Aid in Dyspepsia Management

    Published on: June 29, 2019

    6.3K
    Cooling or Warming the Esophagus to Reduce Esophageal Injury During Left Atrial Ablation in the Treatment of Atrial Fibrillation
    06:25

    Cooling or Warming the Esophagus to Reduce Esophageal Injury During Left Atrial Ablation in the Treatment of Atrial Fibrillation

    Published on: March 15, 2020

    12.9K

    Area of Science:

    • Gastroenterology
    • Digestive Health
    • Esophageal Disorders

    Context:

    • Functional heartburn is a prevalent condition often diagnosed when symptoms persist despite proton pump inhibitor (PPI) therapy.
    • Diagnosis relies on Rome-III criteria, differentiating it from gastroesophageal reflux disease (GERD) and non-erosive reflux disease (NERD).
    • Diagnostic tools include endoscopy and 24-hour pH monitoring to exclude other esophageal conditions.

    Purpose:

    • To define functional heartburn and outline its diagnostic considerations.
    • To highlight the empirical nature of current treatment strategies due to a lack of clinical trials.
    • To emphasize key components of successful management for functional heartburn.

    Summary:

    • Functional heartburn is characterized by symptoms not improving with standard acid suppression therapy.
    • Differential diagnosis involves excluding GERD, NERD, and hypertensive esophagus through specific investigations.
    • Effective management hinges on patient education, precise symptom recognition, and establishing achievable treatment objectives.

    Impact:

    • Provides a framework for understanding and managing functional heartburn.
    • Highlights the need for evidence-based treatment guidelines.
    • Improves patient outcomes through structured and realistic therapeutic approaches.