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Published on: January 20, 2023
Chloranthones A - D: minor and unprecedented dinor-eudesmenes from Chloranthus elatior
Shu-Ting Liu1, Juan Xiong, Yu Tang
1Department of Natural Products Chemistry, School of Pharmacy, Fudan University, No. 826 Zhangheng Rd., Shanghai 201203, P. R. China, (phone/fax: +86-21-51980172); Department of Natural Products for Chemical Genetic Research, Key Laboratory of Brain Functional Genomics, Ministry of Education, East China Normal University, No. 3663 North Zhongshan Rd., Shanghai 200062, P. R. China.
Abstract:
Four novel naturally occurring diastereoisomers of dinor-eudesmenes, named chloranthones A-D (1-4, resp.), were isolated as minor components from the EtOH extract of the aerial parts of Chloranthus elatior. The unprecedented framework was established using extensive 2D-NMR techniques. Their absolute configurations were deduced from the observed Cotton effects in their circular dichroism (CD) spectra. A plausible biosynthetic pathway to the dinor-eudesmenes is proposed.
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