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Valvular heart disease associated with long-term treatment by methysergide: a case report
Michel Andréjak1, Catherine Szymanski2, Sylvestre Maréchaux3
1Service de Pharmacologie clinique, Centre régional de Pharmacovigilance de Picardie, Centre hospitalier universitaire Sud d'Amiens, Amiens, France - INSERM U 1088, Université de Picardie, Amiens, France.
Abstract:
This case report concerns a woman treated continuously since at least 10 years by methysergide for cluster headache. The echocardiographic and histological features of the severe valve fibrosis presented by this patient are very similar to those described with 5 HT(2B) receptors agonistic drugs.
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