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Neurogenesis and Regeneration of Nervous Tissue

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In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...

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Related Experiment Video

Updated: Apr 28, 2026

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

Published on: January 10, 2018

Biologic scaffold for CNS repair.

Fanwei Meng¹, Michel Modo, Stephen F Badylak

¹McGowan Institute for Regenerative Medicine, University of Pittsburgh, Pittsburgh, PA 15203, USA.

Regenerative Medicine

|June 18, 2014

Summary

Extracellular matrix scaffolds from mammalian tissues show promise for central nervous system (CNS) repair and dural mater reconstruction. These cell-free scaffolds leverage natural bioactive molecules to aid in tissue regeneration after CNS injury.

Keywords:

CNS ECM biologic scaffold constructive remodeling decellularization regeneration

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Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

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Last Updated: Apr 28, 2026

Three-dimensional Tissue Engineered Aligned Astrocyte Networks to Recapitulate Developmental Mechanisms and Facilitate Nervous System Regeneration

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Published on: January 10, 2018

Anatomically Inspired Three-dimensional Micro-tissue Engineered Neural Networks for Nervous System Reconstruction, Modulation, and Modeling

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Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Injection of Hydrogel Biomaterial Scaffolds to The Brain After Stroke

Published on: October 1, 2020

Area of Science:

Regenerative Medicine
Biomaterials Science
Neuroscience

Background:

Central nervous system (CNS) injuries often lead to severe disability due to limited endogenous repair.
Biologic scaffolds can aid CNS tissue reconstruction, with extracellular matrix (ECM) scaffolds showing recent promise.
Dural mater repair is clinically important for CNS barrier function and homeostasis.

Purpose of the Study:

To describe the application of regenerative medicine principles for CNS tissue and dural mater repair.
To highlight the use of cell-free extracellular matrix scaffolds derived from mammalian tissues.

Main Methods:

Utilizing extracellular matrix scaffolds derived from mammalian tissues.
Focusing on scaffolds free of cells and exogenous factors.
Applying regenerative medicine strategies to CNS and dural mater repair.

Main Results:

Extracellular matrix scaffolds retain bioactive molecules beneficial for CNS repair.
Mammalian-derived ECM scaffolds offer potential for functional tissue reconstruction.
Novel biomaterials are of clinical interest for dural mater repair.

Conclusions:

Cell-free extracellular matrix scaffolds represent a promising strategy for CNS and dural mater repair.
These scaffolds leverage inherent biological cues for tissue regeneration.
Further application of regenerative medicine principles can advance CNS therapeutic strategies.