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[Radiation therapy in brain metastases].

M Tsuchiya¹, J Shinozaki, I Hashida

¹Dept. of Radiotherapy, Cancer Institute Hospital.

Gan No Rinsho. Japan Journal of Cancer Clinics

|January 1, 1989

Summary

Hypervoltage irradiation for brain metastases improved neurological function and survival. Higher doses (over 50 Gy) with whole brain irradiation and boost therapy may offer better long-term control for localized brain lesions.

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Enhanced cytotoxicity in combination of low dose-rate irradiation with hyperthermia in vitro.

International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group·1996

Area of Science:

Oncology
Radiation Oncology
Neurosurgery

Context:

Brain metastases pose a significant challenge in cancer care.
Effective treatment strategies are crucial for improving patient outcomes.

Purpose:

To evaluate the efficacy of hypervoltage irradiation for brain metastases.
To identify factors influencing survival and neurological improvement.

Summary:

126 patients with brain metastases received hypervoltage irradiation.
Patients without extracranial metastases or neurological symptoms had longer survival.
Radiotherapy exceeding 30 Gy improved neurological function and reduced mortality risk.

Impact:

Whole brain irradiation with boost therapy may enhance local control of brain metastases.

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Total doses potentially exceeding 50 Gy might be necessary for long-term management.

Findings inform radiation dose and technique selection for brain metastases.