Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[BCG multifocal osteomyelitis. A case report].

H Ben Ghozlen1, M Jerbi1, Y Zitoun1

  • 1Service d'orthopédie, hôpital Tahar Sfar, Mahdia, Tunisie.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|June 18, 2014
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

Bacterial Meningitis I: Introduction01:22

Bacterial Meningitis I: Introduction

11
Bacterial meningitis is a severe, life-threatening inflammation of the meninges, particularly the pia mater and arachnoid mater, affecting the subarachnoid space, ventricles, and cerebrospinal fluid (CSF). If untreated, it can lead to significant neurological complications or death.Causative AgentsCommon pathogens vary with age and immune status. In adults, major organisms include Streptococcus pneumoniae, Neisseria meningitidis, and Haemophilus influenzae. Streptococcus agalactiae (group B...
11

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Double optic disc: True duplication or coloboma?]

Journal francais d'ophtalmologie·2022
Same author

Correction: In-silico analysis of interacting pathways through KIM-1 protein interaction in diabetic nephropathy.

BMC nephrology·2022
Same author

In-silico analysis of interacting pathways through KIM-1 protein interaction in diabetic nephropathy.

BMC nephrology·2022
Same author

Evaluation of in vitro anticancer potential of pharmacological ethanolic plant extracts Acacia modesta and Opuntia monocantha against liver cancer cells.

Brazilian journal of biology = Revista brasleira de biologia·2022
Same author

[Transient monocular blindness following intra-oral local anesthesia: Case report].

Journal francais d'ophtalmologie·2018
Same author

[Post-traumatic macular hematoma as presenting sign of angioid streaks: Role of spectral-domain optical coherence tomography (SD-OCT)].

Journal francais d'ophtalmologie·2018
Same journal

Family experiences of paediatric palliative care during hospital-at-home: a systematic review.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2026
Same journal

Knowledge of maternity caregivers on vaccination BCG recommendations and circuits.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2026
Same journal

"CRANIOQUALITY study: Quality of life in children with non-syndromic craniosynostosis after surgery".

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2026
Same journal

Chronological evolution of brain imaging of hemiconvulsion-hemiplegia-epilepsy from 5 cases in Mayotte island.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2026
Same journal

Point-of-care capillary blood ketone testing to predict the need for intravenous or nasogastric tube rehydration in children with acute gastroenteritis.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2026
Same journal

Transition practices of patients with inflammatory bowel disease from pediatric to adult healthcare systems. Results from a national survey.

Archives de pediatrie : organe officiel de la Societe francaise de pediatrie·2026
See all related articles

Multifocal osteomyelitis is a rare complication following Bacille Calmette-Guerin (BCG) vaccination, especially in immunocompromised children. This case highlights the diagnostic challenges and fatal outcome in an infant with severe combined immunodeficiency.

Area of Science:

  • Pediatrics
  • Infectious Diseases
  • Immunology

Background:

  • The Bacille Calmette-Guerin (BCG) vaccine is widely used for tuberculosis prevention.
  • Multifocal osteomyelitis is an uncommon but serious adverse event associated with BCG vaccination.
  • Immunocompromised individuals are at higher risk for disseminated BCG infections.

Observation:

  • A 6-month-old infant received a postnatal BCG vaccination.
  • The infant subsequently developed extensive, disseminated skeletal osteomyelitis.
  • Severe combined immunodeficiency (SCID) was diagnosed in the affected child.

Findings:

  • BCG vaccination can lead to multifocal osteomyelitis in susceptible infants.
  • Disseminated skeletal infection in this context is challenging to diagnose.

Related Experiment Videos

  • The infant's condition was refractory to standard antibiotic treatment and bone marrow transplantation.

    • Implications:

    • Early recognition of disseminated BCG infection is crucial in immunocompromised infants post-vaccination.
    • This case underscores the need for vigilant monitoring for osteomyelitis in infants with SCID.
    • Further research may be needed to improve treatment strategies for disseminated BCG osteomyelitis in immunocompromised populations.