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Updated: Apr 28, 2026

Subretinal Transplantation of Human Embryonic Stem Cell-Derived Retinal Tissue in a Feline Large Animal Model
Published on: August 5, 2021
Transplantation of embryonic and induced pluripotent stem cell-derived 3D retinal sheets into retinal degenerative
Juthaporn Assawachananont1, Michiko Mandai2, Satoshi Okamoto3
1Laboratory for Retinal Regeneration, RIKEN Center for Developmental Biology, Kobe 650-0047, Japan ; Graduate School of Medicine, Kyoto University, Kyoto 606-8501, Japan.
Abstract:
In this article, we show that mouse embryonic stem cell- or induced pluripotent stem cell-derived 3D retinal tissue developed a structured outer nuclear layer (ONL) with complete inner and outer segments even in an advanced retinal degeneration model (rd1) that lacked ONL. We also observed host-graft synaptic connections by immunohistochemistry. This study provides a "proof of concept" for retinal sheet transplantation therapy for advanced retinal degenerative diseases.

