Related Experiment Video
Updated: Apr 28, 2026

Reducing State Anxiety Using Working Memory Maintenance
Published on: July 19, 2017
Cardiovascular reflexes during treatment of social phobia with moclobemide
Introduction:
Cardiovascular side-effects are less frequent with moclobemide than with tricyclic or monoamine oxidase inhibitor antidepressants. We performed a detailed assessment of cardiovascular reflexes in 15 patients meeting DSM-III-R criteria for social phobia, before treatment and whilst taking a stable dose of moclobemide for a median of 7 weeks.
Method:
Cardiovascular reflex responses to standing, deep breathing and the Valsalva manoeuvre were assessed using beat-by-beat blood pressure and heart rate recording.
Results:
Moclobemide produced a statistically significant, but clinically modest, degree of improvement in social phobia symptoms. Only the maximum change in heart rate from supine to standing showed a change from before to after treatment, which was not statistically significant after Bonferroni correction, and there was no consistent pattern of altered sympathetic or parasympathetic function.
Conclusion:
Moclobemide is relatively devoid of cardiovascular autonomic effects in physically healthy subjects with social phobia. ( Int J Psych Clin Pract 2001; 5:27-31).
More Related Videos
Related Concept Videos
Social Anxiety Disorder
Anxiety: Overview
Individuals with anxiety often experience a range of physical and emotional symptoms, including sweating, trembling, tachycardia, and disturbances in sleep patterns. These symptoms vary in intensity and frequency but are generally disruptive and distressing.
Anxiolytic Drugs: Overview
Primary Types of Anxiolytic Drugs
1. Benzodiazepines:
Benzodiazepines bind to the GABA-A receptor in the brain, enhancing GABA's interaction. This action reduces neurotransmission, effectively blocking anxiety-associated limbic...
Anxiolytic Drugs: Benzodiazepines and Buspirone
Generalized Anxiety Disorder
Antidepressant Drugs: MAOIs and Other Agents

