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Related Concept Videos

Skin Cancer01:30

Skin Cancer

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Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
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Metastasis is the spread of cancer cells from the original site to distant locations in the body. Cancer cells can spread via blood vessels (hematogenous) as well as lymph vessels in the body.
Epithelial-to-Mesenchymal Transition
The epithelial-to-mesenchymal transition or EMT is a developmental process commonly observed in wound healing, embryogenesis, and cancer metastasis. EMT is induced by transforming growth factor-beta (TGF-β) or receptor tyrosine kinase (RTK) ligands, which further...
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Renewal of Skin Epidermal Stem Cells01:12

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The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular...
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Abnormal Proliferation02:23

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Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
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Cancer Stem Cells and Tumor Maintenance02:40

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Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
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Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
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Related Experiment Video

Updated: Apr 28, 2026

Combining Reflectance Confocal Microscopy with Optical Coherence Tomography for Noninvasive Diagnosis of Skin Cancers via Image Acquisition
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Advanced, neglected basal cell carcinoma.

Lauren E Wiznia1, Kerry M Shanley1, Daniel G Federman1

  • 1From the Yale University School of Medicine and the VA Connecticut Healthcare System, New Haven, Connecticut, and the Massachusetts Eye and Ear Infirmary, Boston.

Southern Medical Journal
|June 18, 2014
PubMed
Summary

Basal cell carcinoma (BCC), a common skin cancer, rarely spreads but causes significant health burdens. Early diagnosis and management are crucial for better patient outcomes and reduced healthcare costs.

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Area of Science:

  • Dermatology
  • Oncology
  • Public Health

Background:

  • Basal cell carcinoma (BCC) is a prevalent skin malignancy with a high cure rate when detected early.
  • Despite its generally favorable prognosis, BCC contributes significantly to patient morbidity and global healthcare expenditure.
  • Late-stage presentations of BCC pose treatment challenges and are associated with poorer outcomes.

Purpose of the Study:

  • To highlight the consequences of neglected basal cell carcinoma.
  • To emphasize the importance of early diagnosis and management of BCC.
  • To inform healthcare professionals about risk factors for earlier patient engagement.

Main Methods:

  • Literature review on BCC prevalence, morbidity, and treatment outcomes.
  • Analysis of healthcare system burden associated with BCC.
  • Discussion of clinical strategies for early BCC detection.

Main Results:

  • Early BCC diagnosis is associated with >95% cure rates.
  • Neglected BCCs lead to increased morbidity and complex treatment scenarios.
  • Identifying patient risk factors can facilitate earlier diagnosis and intervention.

Conclusions:

  • Healthcare professionals must be aware of the impact of delayed BCC diagnosis and treatment.
  • Proactive identification of at-risk individuals is key to mitigating BCC-related morbidity.
  • Timely management of basal cell carcinoma is essential for improving patient outcomes and reducing healthcare burdens.