Correlation between retinal nerve fiber layer and disc parameters in glaucoma suspected eyes

Area of Science:

• Ophthalmology
• Medical Imaging
• Glaucoma Research

Background:

• Glaucoma diagnosis relies on detecting progressive optic nerve damage.
• Accurate quantification of optic nerve head (ONH) parameters is essential for early glaucoma detection and monitoring.

Purpose of the Study:

• To evaluate the diagnostic accuracy of spectral-domain optical coherence tomography (SD-OCT) parameters.
• To assess SD-OCT's ability to differentiate between healthy eyes and various stages of glaucoma.

Main Methods:

• A retrospective cross-sectional study involving 180 eyes from 140 patients.
• Utilized Copernicus Spectra-domain OCT for optic nerve head imaging.
• Eyes were categorized into four groups: healthy, early, developed, and terminal glaucoma.

Main Results:

• Significant differences in cup-to-disc ratio (E/D) and cup volume were observed across glaucoma stages.
• Terminal glaucoma showed significantly reduced retinal nerve fiber layer (RNFL) thickness compared to other groups.
• Disc size did not significantly differ between developed glaucoma and healthy eyes.

Conclusions:

• SD-OCT is a valuable tool for quantifying ONH anatomy in glaucoma assessment.
• Detected ONH changes using SD-OCT serve as important indicators of glaucoma progression and risk.
• SD-OCT provides an accurate model for understanding glaucoma pathology.