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Studies on lysine:N6-hydroxylation by cell-free systems of Aerobacter aerogenes 62-1
C J Goh1, E W Szczepan, N Menhart
1Guelph-Waterloo Centre for Graduate Work in Chemistry, University of Waterloo, Canada.
Biochimica Et Biophysica Acta
|March 24, 1989
Abstract:
Electron microscopic examination has revealed the vesicular nature of the membrane component, of the cell-free system of Aerobacter aerogenes 62-1, which catalyses lysine: N6-hydroxylation. Regardless of the orientation of the vesicles, N-hydroxylation process is still stimulated by pyruvate. Both pyruvate oxidation and lysine: N6-hydroxylation were inhibited by protonophores and Gramicidin S.