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The bm12 Inducible Model of Systemic Lupus Erythematosus SLE in C57BL/6 Mice
Published on: November 1, 2015
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Pain and systemic lupus erythematosus.
M Di Franco1, M P Guzzo, F R Spinelli
1Department of Internal Medicine and Medical Specialties, Rheumatology Unit, La Sapienza University, Rome. manuela.difranco@uniroma1.it.
Reumatismo
|June 19, 2014
Summary
Systemic lupus erythematosus (SLE) patients frequently experience widespread pain and fatigue, often associated with fibromyalgia (FM). Promptly identifying pain origins is crucial for effective SLE and FM management and improving patient quality of life.
Area of Science:
- Rheumatology
- Immunology
- Pain Medicine
Background:
- Systemic lupus erythematosus (SLE) is a complex autoimmune disease with diverse clinical presentations.
- Musculoskeletal pain, including arthralgia, arthritis, and myalgia, are common initial symptoms of SLE.
- Chronic widespread pain, characteristic of fibromyalgia (FM), frequently co-occurs in SLE patients.
Purpose of the Study:
- To review the nature of widespread pain and fatigue in SLE.
- To explore the association between SLE and fibromyalgia (FM).
- To emphasize the importance of differentiating pain origins for optimal patient care.
Main Methods:
- Literature review focusing on SLE, widespread pain, and fibromyalgia.
- Analysis of clinical manifestations and diagnostic criteria for SLE and FM.
- Synthesis of current understanding regarding the comorbidity of SLE and FM.
Main Results:
- Widespread pain and fatigue are significant issues for SLE patients.
- Secondary fibromyalgia is often associated with SLE but not directly correlated with disease activity.
- Distinguishing between SLE-related pain and fibromyalgia is essential for appropriate treatment.
Conclusions:
- Identifying the specific cause of pain in SLE is critical to prevent undertreatment or overtreatment.
- Prompt diagnosis and management of fibromyalgia symptoms in SLE patients can improve daily functioning and quality of life.
- Further research may elucidate the mechanisms underlying the frequent association between SLE and fibromyalgia.
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