Pain in Sjögren's syndrome

Area of Science:

• Rheumatology
• Immunology
• Pain Medicine

Background:

• Sjögren's syndrome (SjS) is an autoimmune disorder primarily targeting salivary and lacrimal glands.
• Extra-glandular manifestations are common in SjS, with pain being a frequently reported symptom.
• Patients with SjS often experience neuropathic pain, and sometimes nociceptive pain, which can be associated with fibromyalgia.

Purpose of the Study:

• To conduct a scientific literature analysis on the presence and characteristics of pain in patients with primary Sjögren's syndrome.
• To consolidate current understanding of pain as a symptom in SjS.
• To highlight the need for further research into pain mechanisms and management in SjS.

Main Methods:

• Systematic review of existing scientific literature.
• Analysis of studies focusing on pain symptoms in primary SjS.
• Literature search using relevant keywords related to SjS and pain.

Main Results:

• Pain is a significant and common symptom in primary SjS.
• Neuropathic pain is the predominant type reported by SjS patients.
• The co-occurrence of nociceptive pain with widespread symptoms, indicative of fibromyalgia, is noted.

Conclusions:

• Pain, particularly neuropathic pain, is a prevalent and important manifestation in primary SjS.
• Further research is warranted to fully understand and manage pain in SjS patients.
• Addressing pain is crucial for improving the quality of life for individuals with SjS.