Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Modified-Release Drug Delivery Systems: Rate-Programmed II01:19

Modified-Release Drug Delivery Systems: Rate-Programmed II

137
Rate-programmed drug delivery systems release drugs in a controlled manner to maintain therapeutic levels. Three main designs include reservoir, matrix, and hybrid systems.Reservoir systems consist of a drug core enclosed within a membrane that controls drug release. In non-swelling reservoir systems, polymers like ethyl cellulose or polymethacrylates are used. These do not hydrate in aqueous media and control release through membrane thickness, porosity, or insolubility. This type includes...
137
Modified-Release Drug Delivery Systems: Rate-Programmed I01:22

Modified-Release Drug Delivery Systems: Rate-Programmed I

168
Rate-programmed drug delivery systems (DDS) are designed to release drugs at specific, controlled rates to maintain consistent therapeutic levels. These systems are categorized based on their release mechanisms, including dissolution-controlled DDS, diffusion-controlled DDS, and combined dissolution-diffusion-controlled DDS.In dissolution-controlled DDS, the release rate depends on the slow dissolution of the drug itself or the surrounding matrix. Drugs with inherently slow dissolution rates,...
168

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Polymer Molecular Weight Influences Cancer Cell Surface Retention and Cytokine Presentation by Layer-by-Layer Nanoparticles.

ACS nano·2026
Same author

Engineering nanoparticle surface chemistry for antigen-presenting cell targeting improves specificity and safety of TLR3 agonist cancer immunotherapy.

bioRxiv : the preprint server for biology·2026
Same author

Bacteriophage-mediated cell lysis externalizes a metabolically valuable nutrient to broadly modulate bacterial communities.

The ISME journal·2026
Same author

Polyelectrolyte nanoparticles enable intracellular delivery of STING protein fragments for ovarian cancer immunotherapy.

Materials today. Bio·2026
Same author

A multivalent peptide-polymer conjugate material mimics STING to therapeutically activate innate immune signaling.

bioRxiv : the preprint server for biology·2026
Same author

PEG chains modulate electrostatic interactions between PAMAM and articular cartilage.

Biomaterials·2026

Related Experiment Video

Updated: Apr 28, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

9.9K

Ordered and kinetically discrete sequential protein release from biodegradable thin films.

Bryan B Hsu1, Kelsey S Jamieson, Samantha R Hagerman

  • 1Koch Institute for Integrative Cancer Research and the Institute for Soldier Nanotechnologies, Massachusetts Institute for Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA); Department of Chemistry, Massachusetts Institute for Technology, 77 Massachusetts Avenue, Cambridge, MA 02139 (USA).

Angewandte Chemie (International Ed. in English)
|June 19, 2014
PubMed
Summary

This study developed a novel method for controlled sequential protein release from films using bioorthogonal cross-linking. This approach prevents drug burst release and maintains protein activity for localized therapies.

Keywords:
click chemistrycontrolled releasedrug deliverypolyelectrolyte multilayersstaged release

More Related Videos

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
11:13

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

7.8K
Fabrication of Large-area Free-standing Ultrathin Polymer Films
10:08

Fabrication of Large-area Free-standing Ultrathin Polymer Films

Published on: June 3, 2015

15.1K

Related Experiment Videos

Last Updated: Apr 28, 2026

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries
10:58

Combinatorial Synthesis of and High-throughput Protein Release from Polymer Film and Nanoparticle Libraries

Published on: September 6, 2012

9.9K
Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules
11:13

Composite Scaffolds of Interfacial Polyelectrolyte Fibers for Temporally Controlled Release of Biomolecules

Published on: August 19, 2015

7.8K
Fabrication of Large-area Free-standing Ultrathin Polymer Films
10:08

Fabrication of Large-area Free-standing Ultrathin Polymer Films

Published on: June 3, 2015

15.1K

Area of Science:

  • Biomaterials Science
  • Drug Delivery Systems
  • Polymer Chemistry

Background:

  • Multidrug regimens are crucial for recalcitrant diseases when single-drug therapies fail.
  • Controlled release films for localized multidrug delivery face challenges due to intertwined release kinetics and uncontrollable burst release.

Purpose of the Study:

  • To develop a method for controlled sequential protein release from biodegradable films.
  • To address challenges in multidrug administration and localized delivery.

Main Methods:

  • Utilized layer-by-layer assembly with biodegradable, naturally derived components.
  • Employed copper-free click chemistry for bioorthogonal covalent cross-linking within the film.
  • Incorporated barrier layers and spatially distributed protein-containing layers for sequential release.

Main Results:

  • Achieved kinetic control over protein release by cross-linking films during assembly.
  • Restricted protein interdiffusion while preserving protein activity.
  • Demonstrated well-defined sequential protein release with minimal overlap, correlating with spatial distribution.

Conclusions:

  • The developed strategy enables precise control over sequential protein release from films.
  • This method offers a promising approach for localized, controlled multidrug delivery systems.
  • The technique maintains protein integrity and activity, overcoming previous limitations.