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Related Experiment Video

Updated: Apr 28, 2026

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Memantine enhances recovery from stroke.

Héctor E López-Valdés1, Andrew N Clarkson1,2, Yan Ao3

  • 1Neurology, David Geffen School of Medicine at UCLA.

Stroke
|June 19, 2014
PubMed
Summary
This summary is machine-generated.

Memantine treatment improved stroke recovery in mice by enhancing brain plasticity and vascularization, not by reducing infarct size. This suggests potential for clinical translation in stroke rehabilitation.

Keywords:
brain-derived neurotrophic factormemantine

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Area of Science:

  • Neuroscience
  • Stroke Research
  • Pharmacology

Background:

  • Stroke treatment faces limitations due to narrow therapeutic windows and preclinical-to-clinical translation failures.
  • Poststroke plasticity offers a therapeutic target for recovery-modulating agents.
  • Memantine, an NMDA receptor antagonist, is a well-tolerated drug used for Alzheimer disease.

Purpose of the Study:

  • To investigate the efficacy of memantine in promoting poststroke recovery.
  • To explore the mechanisms underlying memantine's effects on stroke outcomes.

Main Methods:

  • Mice received chronic memantine (30 mg/kg/day) or vehicle in drinking water starting >2 hours after photothrombotic stroke.
  • Evaluated motor control using cylinder and grid-walking tests.
  • Assessed sensory map changes via optical intrinsic signal imaging.
  • Quantified astrogliosis, vascular density, and neurotrophic factor signaling (BDNF, pTrkB).

Main Results:

  • Memantine treatment led to significant improvements in motor control and sensory map recovery at 28 days poststroke.
  • No differences in infarct size or initial behavior were observed between groups.
  • Increased vascular density, reduced reactive astrogliosis, and elevated BDNF/pTrkB signaling were noted in memantine-treated mice.

Conclusions:

  • Memantine enhances stroke recovery through mechanisms involving increased BDNF signaling, reduced astrogliosis, and improved vascularization, rather than direct neuroprotection.
  • These findings highlight memantine's potential for clinical application in stroke rehabilitation due to its established safety profile.