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Feedback Inhibition00:46

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Biochemical reactions are occurring constantly in cells, converting starting substances to different products, usually with the help of enzymes that speed the reactions. Without enzymes, it would take far too long for most reactions to occur to be useful to the cell!
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In most cases, excessive hormone production is prevented by negative feedback—a loop that starts with a stimulus inducing the release of a particular substance, like a hormone, to maintain a certain level before triggering a signal that results in a decrease in further release of the hormone.
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Synthesis of new DNA molecules is carried out by the enzyme DNA polymerase, which adds nucleotides on the daughter strand complementary to the template DNA strand. DNA polymerase has a higher affinity to add the correct base and ensures fidelity during DNA replication. Furthermore,  it exhibits proofreading activity during replication, using an exonuclease domain that cuts off incorrect nucleotides from the nascent DNA strand.
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Restraint to Induce Stress in Mice and Rats
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Reply to the editor

Pierre Delaere1, Dirk Van Raemdonck2

  • 1UZ Leuven, ENT Head and Neck Surgery, Leuven, Belgium.

The Journal of Thoracic and Cardiovascular Surgery
|June 19, 2014
PubMed
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No abstract available in PubMed .

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