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Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
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Gut microbiota, probiotics and diabetes.
Aline Corado Gomes, Allain Amador Bueno, Rávila Graziany Machado de Souza
1Laboratório de Investigação em Nutrição Clínica e Esportiva (Labince), Faculdade de Nutrição, Universidade Federal de Goiás, Rua 227 Qd, 68s/nº - Setor Leste Universitário, Goiânia, Goiás, Brazil. jfemota@gmail.com.
Nutrition Journal
|June 19, 2014
Summary
Probiotics may improve diabetes by modulating gut microbiota, reducing inflammation, and enhancing insulin sensitivity. Further research is needed to confirm their role in diabetes prevention and management.
Area of Science:
- Microbiology
- Immunology
- Endocrinology
Background:
- Diabetes mellitus involves complex molecular mechanisms linked to gut microbiota composition and function.
- In type 2 diabetes, gut microbes can trigger inflammatory responses, impairing insulin sensitivity.
- In type 1 diabetes, intestinal changes promote autoimmune destruction of pancreatic beta cells.
Purpose of the Study:
- To review the evidence on the potential of probiotics in managing and preventing diabetes.
- To explore the impact of probiotics on gut microbiota and related molecular pathways in diabetes.
Main Methods:
- Comprehensive literature review of studies in animal models and humans.
- Analysis of research investigating the effects of probiotics on gut microbiota composition and host immune responses.
- Evaluation of studies examining probiotic impact on inflammatory markers, oxidative stress, and intestinal permeability.
Main Results:
- Probiotics demonstrate potential in reducing inflammation and oxidative stress associated with diabetes.
- Evidence suggests probiotics can increase intestinal adhesion protein expression, decrease intestinal permeability, and improve insulin sensitivity.
- Probiotics may also help reduce the autoimmune response implicated in type 1 diabetes.
Conclusions:
- Probiotic administration shows promise for improving diabetes prognosis by modulating the gut microbiota.
- Observed effects include reduced inflammation, oxidative stress, and improved intestinal barrier function.
- Further clinical trials are necessary to establish definitive efficacy for diabetes prevention and management.
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