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Updated: Apr 28, 2026
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Implication of novel thiazolo-thiophene derivative (MCD-KV-10) for management of asthma
Dhiraj Patil1, Ranjeet Prasad Dash, Sandeep Kumar Thakur
1Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research - Ahmedabad, C/O - B. V. Patel Pharmaceutical Education and Research Development (PERD) Centre , S. G. Highway, Thaltej, Ahmedabad, Gujarat , India .
Context:
Asthma is multifaceted disease where many targets contribute towards its development and progression. Among these, adenosine receptor subtypes play a major role.
Objective:
MCD-KV-10, a novel thiazolo-thiophene was designed and evaluated pre-clinically for its implication in management of asthma.
Materials And Methods:
This compound showed good affinity and selectivity towards A(2A)/A3 adenosine receptor (AR) subtypes. Furthermore, MCD-KV-10 was evaluated for in vitro lipoxygenase inhibition activity; in vivo mast cell stabilization potential and in vivo anti-asthmatic activity was done in ovalbumin-induced airway inflammation model in guinea pigs.
Results:
The compound showed good (>57%) inhibition of lipoxygenase enzyme and also effectively protected mast cell degranulation (>63%). The compound showed good anti-asthmatic activity as inferred from the in vivo studies.
Discussion:
These results indicate that MCD-KV-10 has an inhibitory effect on airway inflammation.
Conclusion:
Though, we have identified a potential candidate for management of asthma, further mechanistic studies are needed.
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