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Localized amyloidosis of the upper gingiva: a case report
Tommaso Bucci, Eduardo Bucci, Ana Maria Puig Rullan
1Universiy Federico II, Via S, Pansini, 5 80131 Naples, Italy. p.nuzzolo@hotmail.it.
Journal of Medical Case Reports
|June 19, 2014
Summary
Localized amyloidosis of the gingiva is an extremely rare oral condition. This case highlights the importance of histological and immunohistochemical examination for diagnosis and excluding systemic involvement.
Area of Science:
- Oral pathology
- Head and neck oncology
- Rare diseases
Background:
- Localized amyloidosis is uncommon in the head and neck, typically affecting the tongue or buccal mucosa.
- Oral amyloidosis, particularly in the gingiva, is exceptionally rare.
Observation:
- A 73-year-old man presented with a nodular mass on the upper gingiva.
- Histological examination revealed amorphous and fibrillar amyloid deposits.
- Congo red staining showed characteristic birefringence, and immunohistochemistry confirmed the amyloid component.
Findings:
- The patient was diagnosed with localized primary amyloidosis of the gingiva after excluding systemic involvement.
- No local recurrence or progression to systemic amyloidosis was observed during a 2-year follow-up.
Implications:
- Gingival amyloidosis presents with non-specific clinical features, necessitating thorough diagnostic evaluation.
- Diagnosis relies on histology and immunohistochemistry, complemented by tests to rule out systemic disease.
- Early detection and differentiation from systemic amyloidosis are crucial for patient management.
