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Related Concept Videos

Phase II Reactions: Acetylation Reactions01:24

Phase II Reactions: Acetylation Reactions

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Acetylation, a phase II biotransformation reaction, introduces an acetyl group to drugs or their metabolites. Acetyltransferase enzymes facilitate this reaction, which resembles α-amino acid conjugation due to the addition of a functional group to the drug molecule.
The substrates for acetylation are typically drugs or their metabolites with an amino, sulfonamide, or hydrazine functional group. Acetylation can occur at several points in the drug molecule, including primary, secondary, and...
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Regulated Protein Degradation02:58

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Regulated Protein Degradation02:58

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It is vital to regulate the activity of enzymatic as well as non-enzymatic proteins inside the cell. This can be achieved either through creating a balance between their rate of synthesis and degradation or regulating the intrinsic activity of the protein. Both these regulation mechanisms play an essential role in the normal functioning of cells.
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Spreading of Chromatin Modifications02:25

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The histone proteins in the nucleosomes are post-translationally modified (PTM) to increase or decrease access to DNA. The commonly observed PTMs are methylation, acetylation, phosphorylation, and ubiquitination of lysine amino acids in the histone H3 tail region. These histone modifications have specific meaning for the cell. Hence, they are called "histone code". The protein complex involved in histone modification is termed as "reader-writer" complex.
Writers
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Epigenetic Regulation01:46

Epigenetic Regulation

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Related Experiment Video

Updated: Apr 28, 2026

Deacetylation Assays to Unravel the Interplay between Sirtuins SIRT2 and Specific Protein-substrates
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[SIRT2, a multi-talented deacetylase].

Salwa Sayd1, Marie-Pierre Junier2, Hervé Chneiweiss2

  • 1Équipe plasticité gliale, Neuroscience Paris Seine, CNRS U8246, Inserm U1130, université Pierre et Marie Curie, 7 quai Saint Bernard, 75005 Paris, France - Laboratoire de génétique et pathologie moléculaire, faculté de médecine et de pharmacie de Casablanca, Maroc.

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Summary

Sirtuin 2 (SIRT2) is crucial for resveratrol's anti-cancer effects in human glioblastoma stem cells. Targeting SIRT2 may offer a new therapeutic strategy for brain tumors.

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Area of Science:

  • Biochemistry
  • Molecular Biology
  • Neuro-oncology

Context:

  • Sirtuin 2 (SIRT2) is an NAD(+)-dependent deacetylase with context-dependent functions.
  • Resveratrol exhibits differential effects on neural cells based on their normal or cancerous state.
  • Glioblastoma stem cells represent a challenging target in brain cancer research.

Purpose:

  • To investigate the role of SIRT2 in the antiproliferative action of resveratrol.
  • To explore SIRT2 as a potential therapeutic target for glioblastoma.

Summary:

  • This study demonstrates the involvement of Sirtuin 2 (SIRT2) in mediating the antiproliferative effects of resveratrol.
  • Resveratrol's action against primary human glioblastoma stem cells is linked to SIRT2 activity.
  • Findings highlight SIRT2's specific role in cancer cell biology.

Impact:

  • Identifies SIRT2 as a key mediator in resveratrol's anti-glioblastoma activity.
  • Suggests SIRT2 as a promising therapeutic target for glioblastoma treatment.
  • Contributes to understanding the molecular mechanisms of polyphenol action in cancer.