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Spontaneous background pathology in Göttingen minipigs
Gitte Jeppesen1, Mikala Skydsgaard2
1CitoxLAB Scantox A/S, Lille Skensved, Denmark gn@dk.citoxlab.com.
Toxicologic Pathology
|June 19, 2014
Summary
Göttingen minipigs are increasingly used in nonclinical testing due to their human-like physiology and ethical advantages. This study provides essential background pathology data for 835 untreated control animals.
Area of Science:
- Veterinary Pathology
- Toxicology
- Animal Models
Background:
- Göttingen minipigs are a popular nonrodent model in nonclinical studies.
- They offer anatomical and physiological similarities to humans.
- Ethical considerations favor their use over nonhuman primates and dogs.
Purpose of the Study:
- To establish comprehensive background pathology data for Göttingen minipigs.
- To support the increasing use of this species in regulatory toxicology.
Main Methods:
- Retrospective analysis of 835 untreated control Göttingen minipigs.
- Data collected from animals used between 1995 and 2007.
- Inclusion of both sexes.
Main Results:
- Summary of normal pathological findings in control Göttingen minipigs.
- Characterization of common and rare lesions.
- Establishment of reference ranges for various tissues.
Conclusions:
- Provides a vital reference for interpreting pathology in toxicological studies.
- Supports the continued and expanded use of Göttingen minipigs in nonclinical research.
- Highlights the importance of robust background data for animal models.
