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Steroids: pharmacology, complications, and practice delivery issues
William Ericson-Neilsen1, Alan David Kaye2
1Department of Anesthesiology, Ochsner Clinic Foundation, New Orleans, LA.
Ochsner Journal
|June 19, 2014
Summary
Steroids are widely used for their anti-inflammatory effects but can cause common and problematic side effects, even at low doses. Healthcare providers must understand these risks to avoid exacerbating or causing new medical conditions.
Area of Science:
- Pharmacology
- Immunology
- Clinical Medicine
Background:
- Steroids have been utilized for nearly 80 years in treating various diseases.
- Their primary therapeutic benefits stem from potent anti-inflammatory and immune-modulating properties.
Purpose of the Study:
- To review the fundamental pharmacology of steroids.
- To outline the common complications associated with steroid use.
- To discuss practice delivery issues related to steroid prescription.
Main Methods:
- This study is a comprehensive review of existing literature on steroid pharmacology and clinical use.
Main Results:
- Steroid side effects are frequent and clinically significant, occurring across various doses.
- The route of administration influences the spectrum and severity of side effects.
- Even low-dose steroid regimens can lead to the full range of adverse effects.
Conclusions:
- Healthcare practitioners must recognize that steroids can worsen existing conditions or precipitate new ones.
- A thorough understanding of the clinical implications of steroid therapy is essential for safe patient management.
Keywords:
Adrenal cortex hormonesdiabetes mellitusdrug-related side effects and adverse reactionsglucocorticoidsmedication therapy managementmineralocorticoidsMore Related Videos
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