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1-Cyclo-hexyl-6,7-dimeth-oxy-1,4-di-hydro-naphthalene
Shao-Yuan Chen1, Ya-Ping Zhang1, Bing Huang2
1Institute of Biotechnology, Zhejiang University, People's Republic of China.
Summary
A novel compound, C18H24O2, was identified in Ficus carica L. leaves. Its unique molecular structure features specific ring conformations and intermolecular hydrogen bonding in crystal form.
Area of Science:
- Phytochemistry
- Organic Chemistry
- Crystallography
Background:
- Ficus carica L. (common fig) is a plant with a long history of medicinal use.
- The chemical constituents of Ficus species are of interest for their potential biological activities.
- Isolation and structural elucidation of novel compounds contribute to understanding plant-derived molecules.
Purpose of the Study:
- To isolate and characterize a new chemical compound from Ficus carica L. leaves.
- To determine the three-dimensional structure of the isolated compound using crystallographic methods.
- To investigate the intermolecular interactions in the solid state.
Main Methods:
- Extraction of secondary metabolites from Ficus carica L. leaves.
- Purification of the target compound using chromatographic techniques.
- Single-crystal X-ray diffraction analysis to determine molecular and crystal structure.
Main Results:
- Isolation and identification of a compound with the molecular formula C18H24O2.
- Determination of the crystal structure, revealing a chair conformation for the cyclohexane ring and a flattened boat conformation for the cyclo-hexa-1,4-diene ring.
- Observation of supra-molecular chains formed by weak C-H⋯O hydrogen bonds along the b-axis.
Conclusions:
- The study successfully isolated and characterized a novel compound from Ficus carica L.
- The detailed structural analysis provides insights into the conformational preferences and crystal packing of this molecule.
- The findings contribute to the phytochemical knowledge of Ficus species and the understanding of molecular self-assembly through hydrogen bonding.