Metabolic syndrome in primary gout
Nicolás M González-Senac1, Rebeca Bailén, Rosa J Torres
1a Division of Internal Medicine, Metabolic-Vascular Unit , La Paz University Hospital.
Nucleosides, Nucleotides & Nucleic Acids
|June 19, 2014
Summary
Metabolic syndrome affects about one-third of primary gout patients. This often involves increased waist circumference, blood pressure, and triglycerides, with lower uric acid excretion in those with metabolic syndrome.
Area of Science:
- Nephrology
- Endocrinology
- Cardiology
Background:
- Primary gout is linked to obesity, hypertension, and metabolic issues.
- Prevalence of these vascular risk factors in Mediterranean gout patients is unknown.
Purpose of the Study:
- Determine the prevalence of metabolic syndrome (MS) in Mediterranean primary gout patients.
- Investigate the relationship between MS and uric acid excretion in gout.
Main Methods:
- Studied 104 primary gout patients with ≥2 acute arthritis episodes.
- Diagnosed MS using ≥3 ATP III criteria.
- Classified patients by uric acid excretion: underexcretors vs. normoexcretors.
Main Results:
- 37% of gout patients had MS, most commonly defined by increased waist circumference, blood pressure, and triglycerides.
- Type 2 diabetes mellitus was significantly higher in patients with MS (55%) vs. without (5%).
- Patients with MS showed significantly lower 24-hour uric acid excretion (444 mg/m²) compared to those without MS (546 mg/m²).
Conclusions:
- Metabolic syndrome affects approximately one-third of primary gout patients.
- The most frequent MS triad in this population includes increased waist circumference, blood pressure, and triglycerides.
- Gout patients with MS exhibit more severe diminished urinary uric acid excretion.
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