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ABCG2 dysfunction increases serum uric acid by decreased intestinal urate excretion.

Tappei Takada1, Kimiyoshi Ichida, Hirotaka Matsuo

  • 1a Department of Pharmacy , The University of Tokyo Hospital , Tokyo , Japan.

Nucleosides, Nucleotides & Nucleic Acids
|June 19, 2014
PubMed
Summary

ATP-binding cassette transporter G2 (ABCG2), or breast cancer resistance protein (BCRP), is crucial for intestinal urate excretion. ABCG2 dysfunction reduces intestinal excretion, leading to higher serum uric acid (SUA) levels and increased gout risk.

Keywords:
ABC transporterUrate transporterextra-renal excretiongut excretion

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