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Hyperuricemia in hematologic malignancies is caused by an insufficient urinary excretion
Yoko Oka1, Haruko Tashiro, Ryosuke Sirasaki
1a Department of Internal Medicine , Teikyo University, School of Medicine , Kaga Itabashiku , Tokyo , Japan.
Abstract:
In order to elucidate the mechanism of hyperuricemia in hematologic malignancies, we have retrospectively investigated the uric acid metabolism in 418 chemotherapy-naïve patients with hematologic malignancies. Hyperuricemia was present in 116 (27.8%) of these patients on initial hospitalization. Among 65 hyperuricemic patients analyzed uric acid metabolism, six (9.2%) had overproduction type, 52 (80.0%) had underexcretion type, and seven (10.8%) had a mixed type. Fourteen patients (3.3%) developed tumor lysis syndrome in 418 patients.
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