Related Experiment Video
Updated: Apr 28, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
A study to evaluate the use of extended release divalproex
Michael M Stone1, Robert M A Hirschfeld
1Department of Psychiatry and Behavioral Sciences, University of Texas Medical Branch, Galveston, TX, USA.
Abstract:
BACKGROUND Delayed release divalproex has become a mainstay in the treatment of many psychiatric conditions. An extended release preparation with different pharmacokinetics is now available, but its efficacy in psychiatric patients has yet to be established. METHODS The authors report a retrospective chart review of psychiatric outpatients treated with extended release divalproex. Fourteen charts were identified and reviewed for indications of efficacy and tolerability over a 10-month period. Case reports were provided for four of the patients. RESULTS Of the 14 patients, only one was unable to tolerate the extended release preparation. No patient was discontinued due to lack of efficacy or for safety reasons. Among the patients remaining on the extended release preparation, only minor side effects were reported. CONCLUSIONS This chart review suggests that extended release divalproex was well tolerated and efficacious in a population of psychiatric outpatients. Further studies are needed to validate these findings.
Related Concept Videos
Oral Drug Delivery Systems: Continuous-Release Systems
Modified-Release Drug Delivery Systems: Overview
Antiepileptic Drugs: Potassium Channel Activators
Ezogabine has gained approval as an adjunctive treatment...
Antiepileptic Drugs: Modulators of Neurotransmitter Release Mediated by SV2A Protein
SV2A is a transmembrane glycoprotein located predominantly in the brain, modulating the release of neurotransmitters for neuronal communication. Both levetiracetam and brivaracetam exhibit a high affinity for...
Modified-Release Drug Delivery Systems: Drug Release Characteristics
Depolarizing Blockers: Pharmocokinetics
