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Hepatotoxicity, leucopenia and neutropenia associated with olanzapine therapy
Eleonora Tchernichovsky1, Pinkhas Sirota
1Abarbanel Mental Health Center, Bat-Yam and Sackler Faculty of Medicine, Tel Aviv University, Israel.
Abstract:
Hepatotoxicity, leukopenia and neutropenia are rarely associated with atypical antipsychotic drug therapy. The authors describe a case of a schizophrenic patient, who was treated twice with olanzapine, and who developed an increase of hepatic enzymes, jaundice, reduced WBC, neutropenia, and a high temperature. The patient was diagnosed as suffering from hepatocellular hepatitis, neutropenia and leucopenia. Neuroleptic treatment was discontinued immediately and the patient exhibited consequential clinical improvement. A review of the literature is included.
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