The constituents of Michelia compressa var. formosana and their bioactivities
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Published on: February 2, 2024
Yu-Yi Chan1, Shin-Hun Juang2, Guan-Jhong Huang3
1Department of Biotechnology, Southern Taiwan University of Science and Technology, Tainan 71005, Taiwan. yuyichan@mail.stust.edu.tw.
Abstract:
Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5±0.3 and 9.6±0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7-3.68 μM.
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