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Updated: Apr 28, 2026

Impact Assessment of Repeated Exposure of Organotypic 3D Bronchial and Nasal Tissue Culture Models to Whole Cigarette Smoke
Published on: February 12, 2015
Lung nodule and functional changes in smokers after smoking cessation short-term treatment
Eliana Maci1, Francesca Comito, Anna Maria Frezza
1Department of Medical Oncology, University Campus Bio-Medico , Rome,1,2.
Background:
Tobacco smoke causes lung disfunction and inflammation.
Methods:
Twenty-two consecutive smokers with undetermined lung nodules were included. All underwent a baseline imaging, exhaled carbon monoxide level evaluation and spirometry, repeated at three months from smoking cessation therapy.
Results:
A significant reduction in size of the lung nodules was reported (p = .037) as a trend in number reduction (p = .11). A significant increase in blood arterial oxygen pressure (p < .0001), heart rate reduction (p < .01), and FEV1 increase (p < .0001) was recorded.
Conclusions:
Smoking cessation reduces number and size of lung nodules and improves in lung functionality.
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