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Related Experiment Video

Updated: Apr 28, 2026

Behavioral Characterization of Pentylenetetrazole-induced Seizures: Moving Beyond the Racine Scale
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Panic attacks after treatment with zuclopenthixol decanoate.

Anil Srivastava1, Jorge Soni

  • 1Centre for Addiction and Mental Health and Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada.

International Journal of Psychiatry in Clinical Practice
|June 19, 2014
PubMed
Summary
This summary is machine-generated.

Neuroleptics, used to treat anxiety, may paradoxically cause it. This case study details new-onset panic attacks in a patient treated with zuclopenthixol decanoate, exploring antipsychotic-induced anxiety.

Keywords:
Anxietyantipsychoticsneurolepticspanic attackszuclopenthixol decanoate

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Area of Science:

  • Psychiatry
  • Pharmacology
  • Neuroscience

Background:

  • The relationship between neuroleptic medications and anxiety is complex and not fully understood.
  • While neuroleptics are sometimes prescribed for anxiety, they can also induce anxiety or panic symptoms.

Purpose of the Study:

  • To present a case of new-onset panic attacks associated with zuclopenthixol decanoate treatment.
  • To review existing literature on the association between antipsychotics and anxiety.
  • To explore potential pathophysiological mechanisms underlying antipsychotic-induced anxiety.

Main Methods:

  • Case report presentation.
  • Comprehensive literature review on antipsychotics and anxiety.
  • Discussion of potential biological mechanisms.

Main Results:

  • A patient developed new-onset panic attacks after initiation of zuclopenthixol decanoate, a long-acting antipsychotic.
  • Literature review indicates a complex association, with both anxiolytic and anxiogenic effects reported for antipsychotics.
  • Pathophysiological mechanisms remain to be fully elucidated.

Conclusions:

  • Zuclopenthixol decanoate, like other antipsychotics, may have the potential to induce or exacerbate anxiety and panic symptoms.
  • Further research is needed to clarify the mechanisms by which antipsychotics influence anxiety.
  • Clinical vigilance is required to monitor for anxiety symptoms in patients receiving antipsychotic treatment.