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Updated: Apr 28, 2026

Anatomical Reconstructions of the Human Cardiac Venous System using Contrast-computed Tomography of Perfusion-fixed Specimens
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The influence of contrast media on kidney function in patients with stable coronary artery disease

Simon Bertram Reuter1, Marina Harutyunyan, Naja Dam Mygind

  • 1Department of Cardiology, The Heart Centre, Rigshospitalet, Copenhagen University Hospital and Faculty of Health Sciences, Copenhagen University , Copenhagen , Denmark.

Scandinavian Cardiovascular Journal : SCJ
|June 19, 2014
PubMed

Insights

Few patients with stable coronary artery disease (CAD) developed contrast media-induced nephropathy (CIN) after elective interventions, even without fluid restrictions. However, kidney function did not fully recover in affected individuals within six months.

Area of Science:

  • Cardiology
  • Nephrology
  • Radiology

Background:

  • Contrast media-induced nephropathy (CIN) is a concern in patients undergoing procedures with contrast agents.
  • Stable coronary artery disease (CAD) patients undergoing elective interventions are a population at risk.
  • Understanding CIN incidence and reversibility is crucial for patient management.

Purpose of the Study:

  • To determine the incidence of CIN in stable CAD patients undergoing elective coronary intervention.
  • To assess the reversibility of CIN over a six-month period.
  • To identify predictors of CIN development in this patient cohort.

Main Methods:

  • 447 patients with suspected CAD undergoing elective coronary intervention were enrolled.
  • Hydration involved routine 1000 ml saline infusion with no fluid intake restrictions.
  • Kidney function was assessed via blood samples pre-intervention and 24 hours post-intervention, with a 6-month follow-up.

Main Results:

  • 19 patients (4.3%) developed CIN.
  • CIN patients had higher baseline estimated glomerular filtration rates (eGFR) and lower creatinine levels compared to non-CIN patients.
  • Kidney function did not normalize in CIN patients at the 6-month follow-up; two patients still met CIN criteria.

Conclusions:

  • Routine hydration with saline infusion and no fluid restrictions resulted in a low incidence of CIN in stable CAD patients.
  • Neither kidney function nor contrast media volume predicted CIN development.
  • CIN in this cohort was not fully reversible within six months post-intervention.
Abstract

Keywords:
contrast mediacoronary artery diseaseglomerular filtration rateischemic heart diseasekidney function

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