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Coronary sinus lead extraction in CRT patients with CIED-related infection: risks, implications and outcomes
1Department of General, Visceral, Thoracic and Vascular Surgery, Frankfurt‑Höchst City Hospital, Frankfurt, Germany - lisy90@googlemail.com.
Insights
Coronary sinus (CS) lead extraction in cardiac resynchronization therapy (CRT) systems with infection is feasible and safe. Complete removal of infected cardiac implantable electronic device (CIED) systems is recommended for optimal patient outcomes.
Area of Science:
- Cardiology
- Infectious Diseases
- Medical Device Technology
Background:
- Cardiac resynchronization therapy (CRT) systems are crucial for heart failure management.
- Infections associated with CRT systems pose significant clinical challenges.
- Coronary sinus (CS) lead extraction is a complex procedure, especially in infected patients.
Purpose of the Study:
- To evaluate the risks, implications, and outcomes of CS lead extraction in patients with CRT system infections.
- To assess the safety and efficacy of lead extraction in a cohort of infected patients.
Main Methods:
- Retrospective analysis of 40 transvenous CS lead extraction procedures (2000-2011).
- Inclusion of nine patients with CRT system infections (sepsis, lead/valve endocarditis, pocket infection).
- Comparison of outcomes between infected and non-infected subgroups regarding lead dwell time, extraction methods, complications, and hospitalization.
Main Results:
- Infected leads had significantly longer in situ duration (49.7 months vs. 19.2 months).
- Extraction in infected patients required more aggressive techniques and longer radiation exposure.
- All patients achieved procedural success; however, infected patients experienced more minor complications (44.4% vs. 3.2%) and longer hospitalization (21.4 days vs. 9.6 days).
Conclusions:
- Complete removal of infected CIED systems is supported, even with limited pocket site infection.
- An interdisciplinary approach ensures safe CS lead extraction in high-risk infected patients.
- Excellent outcomes and low complication rates are achievable with appropriate standards.
Aim:
The aim of the study was to examine risks, implications and outcomes of coronary sinus (CS) lead extraction in patients with infections of cardiac resynchronization therapy (CRT) systems.
Methods:
The study included 40 (65.5 ± 11.1 years; 80% male) transvenous CS lead extraction procedures performed between 2000-2011. Nine (22.5%) patients suffered from infection and included one sepsis (11.1%), two (22.2%) of lead and valve endocarditis, and four (44.4%) cases of pocket infection. CS lead extraction in the infection subgroup was performed between 14 days and more than five years after the last CIED-related surgical procedure.
Results:
Totally 42 CS and 35 non-CS leads were extracted. Leads extracted in the infection subgroup were significantly longer in situ (49.7 ± 30.7 months) compared to the non-infection subgroup (19.2 ± 28.6 months). Extraction in infected patients required more aggressive methods and longer exposure to radiation than non-infected. Procedural success without major complications was achieved in all patients. Minor post-procedural complications occurred in four (44.4%) of the infected and one (3.2%) of the non-infected patients and were surgical-related in three cases. Overall hospitalization times were significantly longer for the infection than for the non-infection subgroup (21.4 ± 15 versus 9.6 ± 6.9 days).
Conclusion:
Our results support the concept of complete CIED-system removal in CIED-associated infection, regardless of whether or not infection appears to be limited to the generator pocket site, despite risk of heart failure, patient frailty and a high level of comorbidity. An interdisciplinary approach encompassing appropriate diagnostic, procedural and safety standards allows CS lead extraction in this high-risk subpopulation to be performed with excellent outcomes and low complication rates.
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