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Updated: Apr 28, 2026

Nerve Excitability Assessment in Chemotherapy-induced Neurotoxicity
Published on: April 26, 2012
Acyclovir-Induced Neurotoxicity: A Case Report and Review of Literature
Mohammed Andaleeb Chowdhury1, Nada Derar, Syed Hasan
1Department of Internal Medicine, University of Toledo, Toledo, OH.
Abstract:
Neurotoxicity can develop as a side effect of intravenous acyclovir use in patients with renal impairment. It is underreported in clinical practice and often confused with worsening herpes encephalitis. We present a 69-year-old woman with end-stage renal disease on hemodialysis with acyclovir neurotoxicity treated with daily extended hemodialysis sessions. Daily hemodialysis for extended period may shorten the neurotoxicity period and can help with faster return to normal mentation. A high index of suspicion is warranted to diagnose acyclovir-induced neurotoxicity.
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