Urinary brain-derived neurotrophic factor as a biomarker of executive functioning

Area of Science:

• Neuroscience
• Cognitive Science
• Genetics

Background:

• Neurotrophins, like brain-derived neurotrophic factor (BDNF), are crucial for neuronal health and plasticity.
• BDNF influences cognitive reserves, particularly within the prefrontal cortex.
• Individual differences in executive functions are partly explained by BDNF gene variations.

Purpose of the Study:

• To investigate the relationship between executive functioning and peripheral BDNF levels.
• To determine if in vivo neurochemistry, measured peripherally, correlates with cognitive abilities.
• To explore BDNF as a potential biomarker for cognitive function.

Main Methods:

• Fifty-two healthy young adults underwent a comprehensive executive function test battery.
• Urine samples were collected and analyzed for BDNF levels using enzyme-linked immunosorbent assay.
• BDNF concentrations were adjusted for creatinine levels.

Main Results:

• A positive association was found between BDNF concentration and cognitive flexibility.
• No significant relationship was observed between BDNF levels and working memory, abstract reasoning, response inhibition, or fluency.
• Urinary BDNF levels serve as a valid peripheral biomarker for cognitive function.

Conclusions:

• Cognitive flexibility is specifically associated with in vivo BDNF levels.
• Urinary BDNF is validated as a peripheral biomarker for assessing cognition in healthy adults.