Relationship between genome and epigenome--challenges and requirements for future research

Area of Science:

• Multidisciplinary research integrating genetics, epigenetics, and environmental influences on health.

Background:

• Understanding the complex interplay of genetic, epigenetic, and non-genetic factors across the lifespan is crucial for disease etiology.
• These factors significantly influence an individual's susceptibility to and progression of various diseases.

Discussion:

• The study addresses the multifaceted nature of disease development, considering influences from conception through old age.
• Intergenerational effects of these factors are explored, highlighting the long-term impact on population health.

Key Insights:

• Nine major conclusions provide a framework for future scientific inquiry and policy development.
• The findings emphasize the need for integrated approaches to tackle complex health issues.

Outlook:

• Recommendations are set forth for European-level research agendas and public health policies.
• The vision aims to leverage a comprehensive understanding of health determinants for societal benefit.