N-3 PUFA increase bioavailability and function of endothelial progenitor cells
Valentina Spigoni1, Carlo Lombardi, Monia Cito
1Cardiology, Department of Medical and Surgical Specialties, Radiological Sciences and Public Health. University of Brescia, Italy.
Food & Function
|June 20, 2014
Summary
Omega-3 polyunsaturated fatty acids (n-3 PUFA) enhance endothelial progenitor cell (EPC) function and increase circulating EPC numbers. Dietary fish intake rich in n-3 PUFA improves EPC bioavailability, supporting cardiovascular health.
Area of Science:
- Cardiovascular Biology
- Cellular Biology
- Nutritional Science
Background:
- Emerging data suggest n-3 PUFA positively influence endothelial progenitor cell (EPC) biology.
- Investigating the mechanisms behind these effects is crucial for understanding cardiovascular health.
Purpose of the Study:
- To determine if n-3 PUFA enhance EPC in vitro function.
- To assess if n-3 PUFA improve EPC in vivo bioavailability.
Main Methods:
- Isolated circulating angiogenic cells (CACs) and late-outgrowth EPCs from peripheral blood.
- Assessed EPC viability, tube-formation capacity, and inflammatory marker expression.
- Evaluated circulating EPC numbers in healthy subjects consuming a fish-enriched diet.
Main Results:
- n-3 PUFA significantly improved EPC viability and tube-formation capacity.
- Reduced expression of inflammatory markers like ICAM-1, VCAM-1, TNF-α, MCP-1, and IL-8.
- A fish-enriched diet increased circulating EPC numbers, which returned to baseline after a diet-free period.
Conclusions:
- n-3 PUFA play a beneficial role in enhancing EPC function.
- Dietary n-3 PUFA intake positively impacts EPC bioavailability and number.
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