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Published on: April 19, 2016
Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the virion glycome
Max Crispin1, David J Harvey2, David Bitto3
1Oxford Glycobiology Institute, Department of Biochemistry, University of Oxford, Oxford, United Kingdom Max.Crispin@bioch.ox.ac.uk Thomas.Bowden@strubi.ox.ac.uk.
Abstract:
Uukuniemi virus (UUKV) is a model system for investigating the genus Phlebovirus of the Bunyaviridae. We report the UUKV glycome, revealing differential processing of the Gn and Gc virion glycoproteins. Both glycoproteins display poly-N-acetyllactosamines, consistent with virion assembly in the medial Golgi apparatus, whereas oligomannose-type glycans required for DC-SIGN-dependent cellular attachment are predominant on Gc. Local virion structure and the route of viral egress from the cell leave a functional imprint on the phleboviral glycome.
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