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Related Concept Videos

Atherosclerosis III: Management01:26

Atherosclerosis III: Management

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Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
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Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Atherosclerosis IV: Nursing Management01:23

Atherosclerosis IV: Nursing Management

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Nursing management for a patient with arteriosclerosis involves a comprehensive approach focusing on lifestyle modification, disease monitoring, education, and symptomatic care. Here is an overview of effective nursing strategies:Assessment and Monitoring: Initial and ongoing assessments are crucial. Nurses must document the patient's medical history, including any hypertension, diabetes, hyperlipidemia, and other cardiovascular diseases. Assessments also cover family history and lifestyle...
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Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

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Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
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Peripheral Artery Disease III: Interprofessional Care01:27

Peripheral Artery Disease III: Interprofessional Care

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Heart Failure Drugs: Inhibitors of Renin-Angiotensin System01:26

Heart Failure Drugs: Inhibitors of Renin-Angiotensin System

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The activation of the sympathetic nervous system and the renin-angiotensin-aldosterone system (RAAS) contributes to cardiac remodeling, and inhibiting the RAAS is a pharmacological target in heart failure management. As a result, neurohumoral modulation is a crucial treatment principle for managing heart failure. This approach involves using medications like ACE inhibitors (ACEIs), angiotensin receptor blockers (ARBs), β-blockers, mineralocorticoid receptor antagonists (MRAs), and neutral...
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Synthesis of Monocyte-targeting Peptide Amphiphile Micelles for Imaging of Atherosclerosis
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Potential peptides in atherosclerosis therapy.

Sylvie Marleau1, Katia Mellal, David N Huynh

  • 1Faculté de Pharmacie, Université de Montréal, Montréal, Qué., Canada.

Frontiers of Hormone Research
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Summary
This summary is machine-generated.

Novel therapeutic peptides offer new hope for atherosclerosis treatment, targeting cholesterol, inflammation, and macrophage function when statins fall short.

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Area of Science:

  • Cardiovascular Science
  • Pharmacology
  • Immunology

Background:

  • Atherosclerosis is a primary cause of ischemic heart disease, myocardial infarction, and stroke.
  • Statins do not provide universal benefit for all patients with atherosclerosis.
  • Advances in understanding lipoprotein metabolism, macrophage function, and inflammation have opened new research avenues.

Purpose of the Study:

  • To review potential therapeutic peptides for atherosclerosis.
  • To explore peptide targets including dyslipidemia, macrophage scavenger receptors, cholesterol metabolism, and anti-inflammatory cytokines.

Main Methods:

  • Literature review of current research on therapeutic peptides for atherosclerosis.
  • Focus on novel molecular targets and their relevance to disease mechanisms.

Main Results:

  • Identification of therapeutic peptides targeting key pathways in atherosclerosis.
  • Highlighting peptides that modulate lipid metabolism and inflammation.

Conclusions:

  • Therapeutic peptides represent a promising novel strategy for atherosclerosis treatment.
  • Targeting dyslipidemia, macrophages, and inflammation with peptides may overcome limitations of current therapies.