Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Clearing obstructed feeding tubes.

S P Marcuard1, K L Stegall, S Trogdon

  • 1Department of Medicine, East Carolina University School of Medicine, Greenville, North Carolina 27858-4354.

JPEN. Journal of Parenteral and Enteral Nutrition
|January 1, 1989
PubMed
Summary

Viokase effectively dissolves clotted enteral feeding formulas, preventing feeding tube occlusion. This enzyme solution successfully restored patency in most occluded tubes, offering a promising clinical intervention.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Double-blind placebo-controlled multicentre studies of rebamipide, a gastroprotective drug, in the treatment of functional dyspepsia with or without Helicobacter pylori infection.

Alimentary pharmacology & therapeutics·2001
Same author

Antibiotic prophylaxis in percutaneous endoscopic gastrostomy.

The American journal of gastroenterology·1996
Same author

Insulin-like growth factor I in human gastrointestinal exocrine secretions.

Regulatory peptides·1994
Same author

Omeprazole therapy causes malabsorption of cyanocobalamin (vitamin B12)

Annals of internal medicine·1994
Same author

Aspirating gastric residuals causes occlusion of small-bore feeding tubes.

JPEN. Journal of parenteral and enteral nutrition·1993
Same author

Large-bore feeding tube occlusion by yeast colonies.

JPEN. Journal of parenteral and enteral nutrition·1993

Area of Science:

  • Gastroenterology
  • Medical Devices
  • Biochemistry

Background:

  • Enteral feeding formulas can cause feeding tube occlusion.
  • Occlusion necessitates interventions to restore tube patency.
  • Effective clot dissolution is crucial for maintaining enteral nutrition delivery.

Purpose of the Study:

  • To evaluate the efficacy of various solutions in dissolving clotted enteral feeding formulas.
  • To determine the best method for restoring patency in occluded enteral feeding tubes.
  • To assess the clinical utility of a promising dissolution agent in patients.

Main Methods:

  • In vitro testing of six enteral feeding formulas against six dissolution agents and a control.
  • Blind assessment of clot dissolution scores.
  • In vitro restoration of patency in occluded feeding tubes.
  • Clinical application in 10 patients with occluded feeding tubes using a Drum catheter.

Main Results:

  • Viokase in a pH 7.9 solution demonstrated the best clot dissolution in vitro (p < 0.01).
  • Viokase successfully restored patency in all six tested occluded feeding tubes.
  • Clinical use of Viokase in 10 patients resulted in successful tube clearing in seven cases.

Conclusions:

  • Viokase in pH 7.9 solution is highly effective for dissolving clotted enteral feeding formulas.
  • This enzyme-based approach offers a viable solution for managing feeding tube occlusions.
  • Further investigation is warranted for cases of complex or long-standing occlusions.

Related Experiment Videos