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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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As the name suggests, non-LTR retrotransposons lack the long terminal repeats characteristic of the LTR retrotransposons. Additionally, both LTR and non-LTR retrotransposons use distinct mechanisms of mobilization. Non-LTR retrotransposons are further divided into two classes - Long interspersed nuclear elements (LINEs) and short interspersed nuclear elements (SINEs), both of which occur abundantly in most mammals, including humans. Some of the active non-LTR retrotransposons in humans are L1...
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Related Experiment Video

Updated: Apr 28, 2026

Sequencing Small Non-coding RNA from Formalin-fixed Tissues and Serum-derived Exosomes from Castration-resistant Prostate Cancer Patients
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Long noncoding RNA expression signatures of bladder cancer revealed by microarray.

Yi-Ping Zhu1, Xiao-Jie Bian1, Ding-Wei Ye1

  • 1Department of Urology, Fudan University Shanghai Cancer Center, Fudan University, Shanghai 200032, P.R. China ; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China.

Oncology Letters
|June 20, 2014
PubMed
Summary

This study identified numerous long noncoding RNAs (lncRNAs) with altered expression in bladder cancer tissues. These dysregulated lncRNAs may contribute to bladder cancer development and progression by influencing key cellular pathways.

Keywords:
bladder cancerlong noncoding RNAmicroarray

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Area of Science:

  • Oncology
  • Molecular Biology
  • Genomics

Background:

  • Long noncoding RNAs (lncRNAs) are increasingly recognized as critical regulators in various human cancers.
  • The specific roles and expression patterns of lncRNAs in bladder cancer pathogenesis remain largely uncharacterized.

Purpose of the Study:

  • To perform a genome-wide analysis of lncRNA expression in human bladder cancer.
  • To identify aberrantly expressed lncRNAs that may be involved in bladder cancer development and progression.

Main Methods:

  • Microarray analysis was employed to profile lncRNA and mRNA expression in four pairs of human bladder cancer and matched normal bladder tissues.
  • Quantitative PCR (qPCR) was used to validate microarray findings for selected lncRNAs.
  • lncRNA-mRNA co-expression networks were constructed to explore functional relationships.

Main Results:

  • A total of 3,324 differentially expressed lncRNAs and 2,120 differentially expressed mRNAs were identified (≥2-fold change).
  • 110 lncRNAs showed significant differential expression between tumor and normal tissues (≥8-fold change).
  • lncRNA expression levels strongly correlated with protein-coding gene expression, particularly those involved in p53, cell cycle, and propanoate metabolism pathways.

Conclusions:

  • This study presents the first comprehensive lncRNA expression profile in human bladder cancer.
  • A significant number of aberrantly expressed lncRNAs were identified, suggesting their potential as biomarkers or therapeutic targets.
  • Dysregulated lncRNAs likely contribute to bladder cancer pathogenesis through the regulation of critical cellular pathways.