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Updated: Apr 28, 2026

Preparation Of Neovascular Tissues from Human Glioma Tissues for Quantitative Proteomics Analysis of Tumor Angiogenesis
Published on: March 20, 2026
Related to testes-specific, vespid and pathogenesis protein-1 is regulated by methylation in glioblastoma
Elad Jacoby1, Michal Yalon1, Moshe Leitner2
1Department of Pediatric Hematology and Oncology, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel ; Cancer Research Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Ramat Gan, Tel Aviv 52621, Israel.
Abstract:
Related to testes-specific, vespid and pathogenesis protein-1 (RTVP-1), also known as glioma pathogenesis-related protein 1, is highly expressed and has oncogenic features in glioblastoma (GBM; World Health Organization class IV). Promoter methylation has been found to control RTVP-1 expression in prostate carcinoma, Wilms' tumor, acute myeloid leukemia and melanoma. In this bi-institutional study, the methylation status of RTVP-1 in astrocytic brain malignancies (GBM and oligodendroglioma) was examined. The RTVP-1 promoter was hypomethylated in GBM compared with non-tumor brain samples, but was hypermethylated in oligodendroglioma. RTVP-1 methylation correlated with RTVP-1 expression at the mRNA level. In GBM, hypermethylation of the RTVP-1 promoter was associated with improved overall survival although with no statistical significance.
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