Olanzapine oro-dispersible (Velotab TM ) - an alternative to depot?

Olanzapine oro-dispersible (Velotab TM ) was introduced to the United Kingdom in May 2000. It rapidly dissolves in the mouth, and therefore patients may find it preferable to swallowing tablets. Another advantage is that the opportunity to hide the medication is much reduced. The study examined the usage of Velotab TM in a forensic psychiatry setting.

Drug expenditure for different classes of antipsychotic was examined for 6 months before and 7 months after the introduction of olanzapine Velotab TM .

The results showed a change in prescribing practice, with a significant inverse correlation between the use of Velotab TM and depot medication.

This suggests that forensic psychiatrists, who may have particular concerns about compliance, had confidence in oro-dispersible administration as an alternative to depot medication. It is suggested that making other neuroleptics available in an oro-dispersible form would allow for a wider choice of atypicals in populations in whom there are significant compliance problems. (Int J Psych Clin Pract 2002; 6: 163-165).