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Updated: Apr 28, 2026

Estimating Bilateral Atrial Function by Cardiovascular Magnetic Resonance Feature Tracking in Patients with Paroxysmal Atrial Fibrillation
Published on: July 20, 2022
Left atrium function in patients with coronary artery disease
Emanuela Facchini1, Anna Degiovanni, Paolo N Marino
1Department of Translational Medicine, Clinical Cardiology, Università del Piemonte Orientale, Azienda Ospedaliero Universitaria 'Maggiore della Carità', Novara, Italy.
Insights
Left atrial size and function are emerging biomarkers for cardiovascular events. Assessing these factors can improve risk prediction in coronary artery disease patients.
Area of Science:
- Cardiology
- Cardiac Imaging
- Biomarkers
Background:
- The left atrium is increasingly recognized as a potential biomarker for cardiovascular and cerebrovascular events.
- Its size and function may offer prognostic insights, particularly in patients with coronary artery disease (CAD).
Purpose of the Study:
- To review the predictive potential of left atrial size and function for cardiovascular disease in the general population.
- To examine the role of left atrial parameters in predicting outcomes for patients with coronary artery disease (CAD).
Main Methods:
- Review of existing literature on left atrial morphology and function.
- Analysis of studies investigating the association between left atrial parameters and cardiovascular events.
- Examination of prognostic relevance in the context of coronary artery disease (CAD).
Main Results:
- Left atrial volume and function assessment show prognostic relevance, especially in CAD patients.
- Studies indicate left atrial volume predicts survival and adverse events post-acute myocardial infarction.
- Left atrial remodeling correlates with brain natriuretic peptide and provides prognostic information after percutaneous coronary interventions.
Conclusions:
- Evaluating left atrial size and function is crucial for understanding ischemic heart pathophysiology.
- These assessments serve as important clinical risk identifiers in patients with coronary artery disease (CAD).
- Future research will likely further elucidate the role of the left atrium in cardiovascular risk stratification.
Purpose Of Review:
The left atrial cavity has recently been identified as a potential biomarker for cardiac and cerebrovascular accidents. This review examines the potential of left atrial size and function in predicting cardiovascular disease in the general population and outcomes in coronary artery disease (CAD) patients.
Recent Findings:
The atrium is perfused primarily by branches of the proximal left circumflex coronary artery (LCx), and depression of the cavity mechanical performance has been demonstrated in experimental studies during LCx occlusion. Thus, left atrial volume and function assessment may have prognostic relevance, particularly in CAD patients. Such a line of thinking, however, is challenged by the widespread notion that the contribution by left atrial chamber morphology and functional quantitation to the risk stratification process after a first cardiovascular event is not adequately considered. However, a number of studies have shown that left atrial volume predicts survival and major adverse events after an acute myocardial infarction. Left atrial remodeling also provides an important overall prognostic information and correlates with brain natriuretic peptide after primary percutaneous coronary interventions.
Summary:
Evaluation of left atrial size and function is currently of great interest and it will be more so in the very near future, given its potential for insights into the pathophysiology of the ischemic heart, which makes it an important clinical risk identifier in CAD patients.
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