Related Experiment Video
Updated: Apr 28, 2026

13:35
Endoscopic Bilateral Nipple-sparing Mastectomy via a Single Axillary Incision with Immediate Pre-pectoral Implant-based Breast Reconstruction
Published on: May 17, 2024
5.8K
Necrotising soft tissue infection following mastectomy
A Subramanian1, G Thomas1, A Lawn1
1The Royal Surrey County Hospital, Guildford, UK.
Journal of Surgical Case Reports
|June 20, 2014
Summary
Necrotising fasciitis is a rare, aggressive soft tissue infection. Prompt treatment including debridement and VAC therapy is crucial for post-mastectomy patients to prevent severe outcomes.
Area of Science:
- Infectious Diseases
- Surgical Pathology
- Oncology
Background:
- Necrotising fasciitis is a rare, rapidly progressive soft tissue infection.
- It can lead to extensive necrosis, systemic sepsis, and death.
- Cases following mastectomy are exceptionally rare, with only two previously reported.
Purpose of the Study:
- To report a rare case of necrotising fasciitis post-mastectomy.
- To highlight the importance of early clinical suspicion and prompt multidisciplinary treatment.
Main Methods:
- Surgical debridement and triangulation.
- Vacuum-assisted closure (VAC©) dressing.
- Skin grafting.
Main Results:
- Successful treatment of severe soft tissue infection post-mastectomy.
- The patient recovered following a combination of surgical interventions and wound management.
Conclusions:
- Necrotising soft tissue infections post-mastectomy are a serious complication.
- High clinical suspicion and aggressive, multidisciplinary treatment are essential.
- Prompt intervention can prevent severe physical and psychological sequelae.
Related Concept Videos
Cellular Injury IV: Necrosis
60
Necrosis is a form of irreversible cell death caused by severe injury such as ischemia, toxins, or trauma. Unlike programmed cell death, it is an uncontrolled, pathological process that typically provokes inflammation in surrounding tissues.Pathophysiologic ChangesNecrosis begins when cells sustain critical damage, leading to swelling of organelles, particularly mitochondria, and rapid ATP depletion. As energy levels decline, membrane ion pumps fail, leading to calcium influx and eventually,...
60
Healing II: Complications
31
Complications during healing arise when tissue repair is altered by local or systemic factors. These changes involve abnormal collagen deposition, altered biomechanics, and reduced vascular supply, impairing restoration of normal structure and function.Loss of FunctionScar tissue differs significantly from the original tissue it replaces. In the skin, fibrosis lacks adnexal structures such as hair follicles, sebaceous glands, and sweat glands. Their absence reduces tactile sensitivity, impairs...
31
Necrosis
5.2K
Necrosis is considered as an “accidental” or unexpected form of cell death that ends in cell lysis. The first noticeable mention of “necrosis” was in 1859 when Rudolf Virchow used this term to describe advanced tissue breakdown in his compilation titled “Cell Pathology”.
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
Morphological Manifestations of Necrosis
Necrotic cells show different types of morphological appearance depending on the type of tissue and infection. In coagulative necrosis, cells become...
5.2K

