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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNAs01:22

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Hypertension II: Pathophysiology01:29

Hypertension II: Pathophysiology

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Hypertension is a chronic condition in which the blood's force against artery walls is excessively high, posing risks such as heart disease. The condition's underlying mechanisms involve complex interactions among the cardiovascular, kidney, and autonomic nervous systems.Renin-Angiotensin-Aldosterone System (RAAS): This system significantly influences blood pressure regulation. When blood pressure decreases, the kidneys secrete renin. This enzyme transforms angiotensinogen, a plasma protein,...
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Hypertension and Regulation of Blood Pressure01:18

Hypertension and Regulation of Blood Pressure

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Hypertension, the most common cardiovascular disease, is diagnosed through repeated measurements of elevated blood pressure. Its risks, including damage to the kidney, heart, and brain, are directly proportional to blood pressure levels. Starting from 115/75 mm Hg, the risk of cardiovascular disease doubles with each increment of 20/10 mm Hg. The diagnosis relies on blood pressure measurements, not on patient symptoms, as hypertension is often asymptomatic until end-organ damage is imminent or...
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Hypertension I: Introduction01:28

Hypertension I: Introduction

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Hypertension is a widespread, long-term medical condition where blood pressure in the arteries remains elevated. It is characterized by systolic blood pressure readings of 130 mm Hg or above or diastolic blood pressure (DBP) readings of 80 mm Hg or higher. Unmanaged hypertension poses significant health risks, making the distinction between primary (or essential) hypertension and secondary hypertension crucial, as their management and implications vary.Primary HypertensionPrimary hypertension,...
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Related Experiment Video

Updated: Apr 27, 2026

In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
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[MicroRNA and hypertension].

Lian Duan, Xing-Jiang Xiong, Jie Wang

    Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica
    |June 21, 2014
    PubMed
    Summary

    MicroRNAs (miRNAs) regulate cellular processes, and their dysregulation contributes to hypertension. Targeting miRNAs offers a promising therapeutic strategy for managing this condition.

    Area of Science:

    • Molecular Biology
    • Genetics
    • Cardiovascular Research

    Context:

    • MicroRNAs (miRNAs) are crucial regulators of cellular functions like proliferation and apoptosis.
    • Deregulation of miRNAs is linked to impaired cellular function and various diseases, including hypertension.
    • Hypertension pathogenesis involves mechanisms such as renin-angiotensin-aldosterone system (RAAS) overactivation and vascular dysfunction.

    Purpose:

    • To review the role of miRNA in hypertension pathogenesis.
    • To explore miRNAs as potential biomarkers for hypertension.
    • To discuss miRNA-based therapeutic strategies for hypertension treatment.

    Summary:

    • This review examines the pathogenesis of microRNAs (miRNAs) in hypertension.
    • It highlights research on miRNAs as biomarkers and therapeutic targets for hypertension.

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  • Advances in miRNA-based approaches for hypertension treatment are discussed.

    • Impact:

    • Understanding miRNA's role in hypertension can lead to novel diagnostic tools.
    • Targeting miRNAs may offer new therapeutic avenues for hypertension management.
    • Stabilizing miRNA expression could be a key strategy in treating hypertension.