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Transient Expression in Nicotiana Benthamiana Leaves for Triterpene Production at a Preparative Scale

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[Sesquiterpenoids from Solanum lyratum].

Xi-Dian Yue, Xi-Dian Yue, Fang Yao

Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica

|June 21, 2014

Summary

Ten novel compounds were isolated from the Solanum lyratum plant. These natural products, including megastigmane and sesquiterpenoid lactones, were identified for the first time from this source.

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A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products

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Published on: October 4, 2019

Area of Science:

Phytochemistry
Natural Product Chemistry
Organic Chemistry

Context:

Solanum lyratum is a plant with a history of traditional medicinal use.
Investigating the chemical constituents of medicinal plants is crucial for discovering new bioactive compounds.
Previous phytochemical studies on Solanum lyratum have not exhaustively identified all its constituents.

Purpose:

To isolate and characterize the chemical constituents of the whole plant of Solanum lyratum.
To identify novel compounds from this plant species.
To contribute to the understanding of Solanum lyratum's phytochemical profile.

Summary:

Ten compounds were isolated and purified from Solanum lyratum using column chromatography, preparative TLC, and Sephadex LH-20.
The structures of the isolated compounds were determined through physico-chemical properties and spectral data analysis.
The identified compounds include megastigmane and sesquiterpenoid lactone derivatives, with all ten being reported from this plant for the first time.

Impact:

This study expands the known phytochemical diversity of the Solanum genus.
The identified compounds may possess potential pharmacological activities warranting further investigation.
Provides a chemical basis for the traditional uses of Solanum lyratum.
Establishes a reference for future research on Solanum lyratum's chemical composition.