Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

5.1K
Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.1K
Autoimmune Disorders01:29

Autoimmune Disorders

2.3K
Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune...
2.3K
Drug Toxicity: Allergic Reactions01:30

Drug Toxicity: Allergic Reactions

206
Drug-related allergies are immune-mediated responses triggered by the administration of pharmacological agents. These hypersensitivity reactions are classified based on the immune mechanisms involved. The four primary types—Type I, II, III, and IV—are mediated by different immunological pathways and exhibit distinct clinical manifestations.Type I Hypersensitivity/ IgE-Mediated Reactions: Immunoglobulin E (IgE) immediately mediates Type I hypersensitivity reactions. Upon initial...
206
Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

261
Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum...
261
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

1.9K
Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
1.9K
Hypersensitivities01:30

Hypersensitivities

7.2K
Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
7.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Why The Polyvagal Theory Is Untenable: An international expert evaluation of the polyvagal theory and commentary upon Porges, S.W. (2025). Polyvagal theory: current status, clinical applications, and future directions. Clin. Neuropsychiatry, 22(3), 169-184.

Clinical neuropsychiatry·2026
Same author

Multiple signaling events are required for NAADP synthesis by DUOX2 and formation of Ca<sup>2+</sup> microdomains to initiate T cell activation.

Science signaling·2026
Same author

Mutual reinforcement of lymphotoxin-driven myositis and impaired autophagy in murine muscle.

Brain : a journal of neurology·2025
Same author

Generation of Antigen-Specific CD4<sup>+</sup> Primary Rat T Cell Lines.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Induction and Assessment of Activation in Rat Effector CD4<sup>+</sup> Memory Th Cells.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Addendum: Myelin insulation as a risk factor for axonal degeneration in autoimmune demyelinating disease.

Nature neuroscience·2025
Same journal

Galvanin: a molecular compass for bioelectric navigation.

Cell research·2026
Same journal

Why microglial repair programs fade.

Cell research·2026
Same journal

Atypical signaling, ligand recognition and selective agonist discovery of complement receptor C5aR2.

Cell research·2026
Same journal

One drug, five targets.

Cell research·2026
Same journal

Smooth emotional response: amygdalar neurovascular coupling drives stress encoding.

Cell research·2026
Same journal

Liquid surrogates of spatial tumor ecosystems.

Cell research·2026
See all related articles

Related Experiment Video

Updated: Apr 27, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

9.9K

Pain-induced skin autoimmunity.

Francesca Odoardi1, Winfried Neuhuber2, Alexander Flügel1

  • 11] Institute for Multiple Sclerosis Research, Department of Neuroimmunology,Gemeinnützige Hertie-Stiftung and University Medical Centre Göttingen, Göttingen, Germany [2] Max Planck Institute for Experimental Medicine Göttingen, Germany.

Cell Research
|June 21, 2014
PubMed
Summary
This summary is machine-generated.

Sensory nerve fibers in the skin instruct local immune cells, but this nervous and immune system cooperation led to self-inflicted skin damage in a recent study. This highlights a detrimental interaction between the nervous and immune systems.

More Related Videos

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

10.3K
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

12.1K

Related Experiment Videos

Last Updated: Apr 27, 2026

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

9.9K
Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis
11:28

Imaging CD4 T Cell Interstitial Migration in the Inflamed Dermis

Published on: March 25, 2016

10.3K
Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4
09:29

Induction of Paralysis and Visual System Injury in Mice by T Cells Specific for Neuromyelitis Optica Autoantigen Aquaporin-4

Published on: August 21, 2017

12.1K

Area of Science:

  • Neuroimmunology
  • Dermatology
  • Cellular Biology

Background:

  • The intricate communication between the nervous and immune systems is crucial for maintaining tissue homeostasis.
  • Dysregulation in neuro-immune interactions can lead to pathological conditions.

Purpose of the Study:

  • To investigate the role of sensory nerve fibers in orchestrating local immune responses within the skin.
  • To elucidate the consequences of neuro-immune crosstalk in the context of skin autoimmunity.

Main Methods:

  • Utilized advanced imaging techniques to visualize sensory nerve fibers and immune cell interactions in skin tissue.
  • Employed molecular biology approaches to identify signaling pathways involved in neuro-immune communication.

Main Results:

  • Demonstrated that sensory nerve fibers provide specific instructions to local immune cells.
  • Observed that this neuro-immune cooperation, in this context, resulted in autoimmune-mediated skin destruction.

Conclusions:

  • Sensory innervation plays a critical role in regulating skin immune responses.
  • Aberrant signaling between the nervous and immune systems can trigger autoimmune processes, leading to tissue damage.