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Updated: Apr 27, 2026

A Fast and Quantitative Method for Post-translational Modification and Variant Enabled Mapping of Peptides to Genomes
Published on: May 22, 2018
Automated peptide mapping and protein-topographical annotation of proteomics data
Pavankumar Videm, Deepika Gunasekaran, Bernd Schröder
1Institute of Molecular Medicine and Cell Research, University of Freiburg, D-79104 Freiburg, Germany. oliver.schilling@mol-med.uni-freiburg.de.
Background:
In quantitative proteomics, peptide mapping is a valuable approach to combine positional quantitative information with topographical and domain information of proteins. Quantitative proteomic analysis of cell surface shedding is an exemplary application area of this approach.
Results:
We developed ImproViser ( http://www.improviser.uni-freiburg.de) for fully automated peptide mapping of quantitative proteomics data in the protXML data. The tool generates sortable and graphically annotated output, which can be easily shared with further users. As an exemplary application, we show its usage in the proteomic analysis of regulated intramembrane proteolysis.
Conclusion:
ImproViser is the first tool to enable automated peptide mapping of the widely-used protXML format.
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