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Updated: Apr 27, 2026

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
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Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis

Habibie, Satoru Yokoyama, Sherif Abdelhamed

    International Journal of Oncology
    |June 21, 2014
    PubMed

    Insights

    Resveratrol targets survivin, a key protein for melanoma cell survival. Suppressing survivin may offer a new therapeutic strategy for treating melanoma patients.

    Area of Science:

    • Oncology
    • Molecular Biology
    • Pharmacology

    Background:

    • Melanoma treatment requires understanding its survival mechanisms.
    • Resveratrol, a natural compound, shows potential as an anti-melanoma agent.

    Purpose of the Study:

    • To investigate the role of survivin in melanoma survival.
    • To determine if resveratrol targets survivin and its downstream pathways.
    • To explore survivin as a therapeutic target for melanoma.

    Main Methods:

    • Treatment of human and murine melanoma cell lines with resveratrol.
    • Analysis of survivin expression and its regulation.
    • Investigation of apoptosis induction and protective effects of survivin overexpression.

    Main Results:

    • Survivin is essential for melanoma cell survival in vitro and in vivo.
    • Resveratrol downregulates survivin transcription by suppressing beta-catenin and STAT3.
    • Overexpression of survivin confers resistance to resveratrol-induced apoptosis.

    Conclusions:

    • Survivin is a critical mediator of melanoma cell survival.
    • Resveratrol effectively targets survivin, offering a potential therapeutic avenue.
    • Targeting survivin presents a promising strategy for melanoma treatment.

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